In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal for either systemic or local effects. The present study an attempt was made to formulate glipizide loaded microspheres using gelatin as a mucoadhesive polymer by emulsion cross linking method using 25%vv glutaraldehyde as a cross linking agent for management of type 2 diabetes mellitus. Formulation and evaluation of mucoadhesive glipizide microspheres. Formulation and evaluation of mucoadhesive glipizide. Jing zeng md, dabr, in practical radiation oncology physics, 2016. Join our mailing list to receive the latest news and updates from our team. Mucoadhesive microspheres have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surfacetovolume ratio, a much more intimate contact with the mucus layer and specific targeting of. Bioadhesive microspheres for bioavailability enhancement of raloxifene hydrochloride. Mucoadhesive microspheres phd thesis in management mucoadhesive microspheres phd thesis in theses and make it of formulation and evaluation of floating microspheres of formulation and evaluation of floating microspheres the developed floating microspheres of famotidine may be used in microspheres of different size and drug ph. Formulation optimization and in vivo evaluation of. Microspheres are, in strict sense, spherical empty particles. Mucoadhesive microparticulate drug delivery system of. University of szeged, department of pharmaceutical technology dr.
Formulation and evaluation of quetiapine fumarate loaded. Tejaswi vignan institute of pharmaceutical sciences deshmukhi, nalgonda. Pdf development and characterization of mucoadhesive. Physicians insert a catheter through the groin into the hepatic artery and deliver millions of microspheres directly to the tumor site. Injectable microsphere based delivery systems have great potential in tissue engineering, since they remove the need for open surgery. Msc thesis it thesis brt thesis pdf llb thesis thesis writing your thesis phd thesis in law at nigeria horticulture thesis masters thesis radiology thesis geography thesis pdf thesis about metaphor thesis statement stadium thesis pdf phd thesis in economics linguistics thesis project thesis phd thesis proposal thesis for vmware mba thesis topics. Although this result was not as good as shown in reference it still demonstrated the high resolution ability of micro sphere which couldn t be achieved by south land realty. Mucoadhesive drug delivery system thesis a refund and we will return the money according to our moneyback mucoadhesive drug delivery system thesis guarantee. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. Triple drug loaded mucoadhesive chitosan polymeric films. Evaluation of oral mucoadhesive microspheres in man on the basis.
Microspheres are made from polymeric, waxy or protective materials that is biodegradable synthetic polymers and modified natural products. Mucoadhesion is a topic of current interest in the design of drug delivery systems. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades. Approximately 55 physicians in the united states use sirtexs sirspheres microspheres in more than 60 medical centers. Jaykar certify that the thesis entitled design and evaluation of buccal tablets of drug loaded microspheres submitted for the award of degree of doctor of philosophy by mr. D thesis i cant forget smiling encouragement throughout and enthusiasm of dr. Development of a mucoadhesive and multiparticulate colon. Microspheres prepared with gelatin as the polymer have been found to be highly mucoadhesive and have been used for the controlled release of many drugs. Gupta institute of pharmacy, bundelkhand university, jhansi. The present study describes two simultaneous approaches to improve its bioavailability, complexation of rhcl with cyclodextrins, and formulation of mucoadhesive microspheres of the complex using different proportions of carbopol and hpmc. Masters thesis, adhiparasakthi college of pharmacy, melmaruvathur. Sampath, a 2012 formulation and evaluation of quetiapine fumarate loaded carbopol 974p mucoadhesive microspheres for the treatment of schizophrenia.
Material and method famotidine was gift sample from finecure p ltd. Mucoadhesive microspheres containing antihypertensive agent. Formulation and in vitro evaluation of ciprofloxacin hydrochloride mucoadhesive microspheres. Microsphere thesis sidney research paper topics adam gopnik essays persuasive adam gopnik essays should movies be hamlet theme analysis essay thesis topics bienvenidos. Mucoadhesive microparticulate drug delivery system of curcumin against helicobacter pylori infection. This is to certify that the dissertation entitled preparation and evaluation of mucoadhesive microspheres of flurbiprofen for gastroretentive. Stomach specific amoxicillin mucoadhesive microspheres j. Writing of metronidazole containing antihypertensive drug delivery. Jaykar certify that the thesis entitled formulation and. Formulation and evaluation of mucoadhesive microspheres of propranolol hydrochloride for sustained drug delivery akash yadav and dinesh kumar jain department of pharmaceutics, college of pharmacy, indore professional studies ips academy, knowledge village, agrabombay road, rajendra nagar, indore madhya pradesh452012, india. E4955 february 2005 with 291 reads how we measure reads.
The mucoadhesive microspheres were prepared by interpolymer complexation and solvent diffusion method. Bioadhesive microspheres for bioavailability enhancement. Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes. University of szeged, department of drug regulatory affairs. In conclusion, the finding of this study explored mucoadhesive microspheres entrapped the antiparkinson drug, rh, and can potentially be applicable for nasal delivery to enhance nose to brain transport using nasal insufflator for improvement of the symptoms of. European union, social funds, pon 20002006, and marie curie early. Bioadhesive microspheres for bioavailability enhancement of. Design, development and evaluation of mucoadhesive. To develop and evaluate therapeutic potential of noval carriers. Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and. Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination.
Senthil a, thakkar hardik r, ravikumar and narayanaswamyv. There can be a number of mucoadhesive drug delivery system thesis reasons why you might not like your order. Mucoadhesive polymers in the treatment of dry x syndrome. Microspheres were pale yellow in color, freeflowing, spherical, and porous in outline. Patil department of pharmaceutics, ashokrao mane college of pharmacy, pethvadgaon, maharashtra, india, 416111. Mucoadhesive drug delivery system is a part of controlled delivery system. Microspheres adhere to the gastrointestinal mucosa and release the drug for a prolonged period of time. Hydroxypropyl methylcellulose acetate maleate hpmcam was used as the phsensitive material, which dissolves around ph 3. Msc thesis it thesis brt thesis pdf llb thesis thesis writing your thesis phd thesis in law at nigeria horticulture thesis masters thesis radiology thesis geography thesis pdf thesis about metaphor thesis statement stadium thesis pdf phd thesis in economics linguistics thesis project thesis phd thesis proposal thesis for vmware mba thesis. Microspheres based drug delivery system has received a wide appreciation due to its flexibility, cost effectiveness and broad regulatory acceptance. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved andor better therapeutic performance of drugs. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a crosslinking agent. Saurashtra university, rajkot for the award of doctor of philosophy in the pharmacy.
The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid. Introduction microspheres can be defined as solid, spherical, free flowing, smooth surface particles ranging in size from 1 to 4m. In addition, some related terms are beads are used alternatively. May 22, 2018 mucoadhesive intranasal microsphere gel formulation of drug galantamine hydrobromide thesis submited for the requirements of the degree of pdf thesis on mucoadhesivemicrospheres thesis on mucoadhesivemicrospheres buy cheap thesis statement about hobbies and interests for asl online do telehealth annotated bibliography now. Mucoadhesive microspheres were prepared by calcium induced ionotropic gelation method. Formulation and invitro evaluation of metronidazole.
C which is in accordance with the standard melting point of theophylline 270274 as per b. Phd thesis, strategies to develop mucoadhesive drug delivery system. The microspheres swelled when in contact with moisture and released the drug, fig. The literature survey reveals that extensive research has been carried out on development of mucoadhesive microspheres containing antidiabetic. Thesis, faculty of pharmacy, uppasala university, sweden. Microsphere brachytherapy using the beta emission of 90 y is used in the treatment of hepatic malignancies. Formulation and invitro evaluation of microspheres presented by k. Current bone filler systems for nonload bearing applications do not fully resorb and only allow regrowth of bone at the implant interface. Phd thesis entitled studies in design and development of stomach specific drug delivery system using various approaches submitted to saurashtra university, rajkot for the award of doctor of philosophy in the pharmacy pharmaceutical sciences under faculty of medicine research guide. Mucoadhesive microspheres prepared by interpolymer. The purpose of research work was to develop and optimize mucoadhesive microspheres of levocetirizine for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy and at the same time increase the local absorption of drug and reducing systemic side effects and also to develop unique delivery system for patients suffering from allergy and rhinitis.
Mucoadhesive microspheres for controlled drug delivery. Mucoadhesive microspheres of amoxicillin, in situ gelling system of famotidine. Mucoadhesive microspheres have advantages like efficient absorption and enhanced bioavailability of the drugs due to a high. Microspheres as a promising mucoadhesive drug delivery system. Mucoadhesive microspheres for gastroretentive delivery of. In some cases, such as for ocular or vaginal formulations, the delivery system is mechanically attached over the membrane. Both promising mucoadhesive buccal sayani and buccal tablets or fewer incessant seizures. Within this thesis, a tissue engineered injectable bone filler was developed and optimised. Intranasal administration of drugs offers an interesting alternative for achieving systemic therapeutic effects of drugs that are comparable to. Of sustained release mucoadhesive ciprofloxacin hcl. Microspheres prepared from admixtures of gelatin and crosslinked chitosan demonstrated some advantage over that prepared from gelatin alone in terms of better controlled release rate of cemetidine.
Formulation and evaluation of mucoadhesive microspheres of amoxicillin trihydrate by using eudragit rs 100 faizi muzaffar1, n. Georgios imanidis for being coreferee of this phd thesis. If we honestly dont meet your expectations, we will issue a refund. A dissertation submitted to the institute of pharmacy. Chitosan loaded mucoadhesive microspheres of gliclazide. The sirspheres microspheres target the liver tumors and spare healthy liver tissue. Development and characterization of mucoadhesive microspheres of ofloxacin ripudaman singh 1, r. The rationale of developing mucoadhesive microspheres are that the formulation will be confined on a biological surface for localized drug delivery and the drug will be released close to the site of action with a consequent enhancement of bioavailability. The problems of frequent administration and variable low bioavailability 4060% after oral administration of conventional dosage forms can be attenuated by designing it in the form of mucoadhesive microspheres which would prolong the residence time at the absorption site to facilitate intimate contact with the absorption surface and thereby. Formulation and evaluation of controlled release microspheres.
Microspheres are manufactured in both solid and hollow form. Hollow microspheres are used as additives to lower the density of a material. Thesis on floating microspheres 410876 akademik istatistik. Formulation and in vitro evaluation of ciprofloxacin. Oct 15, 2015 formulation and invitro evaluation of microspheres 1. The effect of mechanical stimulation on osteogenesis of. Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. Thesis mucoadhesive tablets, phsensitive excipients composition microspheres, etc. Results of preliminary trials indicate that volume of crosslinking agent, time for. Design, development and optimization abstract the purpose of the present research was to develop and characterize mucoadhesive microspheres of curcumin for the potential use of treating gastric adenocarcinoma. Pdf plga based mucoadhesive microspheres for nasal delivery. To overcome inherent drawbacks associated with conventional dosage forms of neostigmine bromide, an attempt is being made in the present research work to develop an alternative drug delivery system in the form of nasal mucoadhesive microspheres to increase the rate and extent of absorption and to reduce the dosing frequency of the formulation. Mucoadhesive microspheres containing antihypertensive.
Formulation and evaluation of mucoadhesive microspheres of. Computer aided drug design phd thesis sample gastroretentive drug delivery system phd thesis. Research paper preparation and characterization of. Robert joseph garmise, phd thesis, the faculty of the university of north carolina. Porous polymer microspheres decorated with a diverse range of functional groups were synthesised by the postpolymerisation chemical modification of beaded polymers via olefin cross metathesis. International journal of engineering science and technology vol. Formulation and evaluation of mucoadhesive microspheres of piroxicam sonali k. Morphology by sem of optimized formulation f1 in vitro drug release the microspheres bearing hpmc k4m and atenolol were spherical in shape and in the range of desired particle size. Evaluation of mucoadhesive properties of chitosan microspheres. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. Mucoadhesive microspheres, polymers, preparation methods, evaluation, applications, drug delivery.
Pharmaceutical applications of mucobioadhesive microspheres interaction of. The advancement of pharmacokinetics has established that the drug should be present above a certain minimum concentration in blood for as long a period as possible for optimum drug therapy. New methodology for the chemical modification of macroreticular polymers is the primary focus of the work presented in this thesis. Chapter 4chapter 4 formulation and evaluation of stomach. The aim of present work was to prepare mucoadhesive microspheres containing clarithromycin, an antih. Pharmaceutics department, ashokrao mane college of pharmacy, peth. Spray drying tenofovir loaded mucoadhesive and phsensitive microspheres. The effect of mechanical stimulation on osteogenesis of cell seeded collagen microspheres shariatzadeh, maryam 2016 the effect of mechanical stimulation on osteogenesis of cell seeded collagen microspheres. Chitosan, thiolated chitosan, carbopol 71g and methocel k15m were used as mucoadhesive polymers.
Mucoadhesive microspheres phd thesis proposal best essay. Gastroretentive drug delivery mucoadhesive microspheres phd thesis proposal example gastroretentive drug delivery system phd thesis sample mucoadhesive microspheres phd thesis examples. The mucoadhesive microspheres were obtained by incorporating glipizide as model drug in xyloglucan as a mucoadhesive polymer and sodium alginate as a gelforming polymer by the orificeionic gelation method. The slow but complete drug release in the stomach is expected to increase bioavailability of the drug as well as its. Gastroretentive drug delivery system phd thesis pdf. This is to certify that the dissertation entitled formulation and in. The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Buccal tablets thesis pdf buccal tablets thesis pdf download. Description and composition of ciprofloxacin hcl microspheres. Although, continuous infusion has been recognized as a superior mode of drug administration to maintain a constant and prolonged rug level in the body such mode of administration entails certain risk and. Formulation and in vitro characterisation of glipizide. Mucoadhesive microspheres of the novel polymer, xyloglucan, have been formulated and their performance characteristics have been systematically evaluated in vitro and in vivo. The aim of the present investigation was to evaluate the potential use of mucoadhesive microspheres for gastroretentive delivery of acyclovir. Preparation and characterization of a novel phsensitive.
523 1383 944 1043 730 297 599 1222 1203 191 270 465 1491 1142 167 871 411 186 1431 806 1544 1487 1566 453 1142 974 1494 1073 849 337 176 1183 774 1163 938 404